![]() In addition to sleep being a foundational part of memory retention, the team at UC Berkeley previously discovered that the declining amount of a person's deep sleep could act as a "crystal ball" to forecast a faster rate of future beta-amyloid buildup in the brain, after which dementia is more likely set in. In recent years, scientists have probed the ways that deposits of beta-amyloid associate with Alzheimer's disease and how such deposits also affect memory more generally. Roughly one in nine people over age 65 have the progressive disease - a proportion that is expected to grow rapidly as the baby boomer generation ages. The research, published Wednesday in the journal BMC Medicine, is the latest in a large body of work aimed at finding a cure for Alzheimer's disease and preventing it altogether.Īs the most prevalent form of dementia, Alzheimer's disease destroys memory pathways and, in advanced forms, interferes with a person's ability to perform basic daily tasks. "One of those factors is sleep and, specifically, deep sleep." "People should be aware that, despite having a certain level of pathology, there are certain lifestyle factors that will help moderate and decrease the effects. "With a certain level of brain pathology, you're not destined for cognitive symptoms or memory issues," said Zsófia Zavecz, a postdoctoral researcher at UC Berkeley's Center for Human Sleep Science. However, the new research from a team at UC Berkeley reveals that superior amounts of deep, slow-wave sleep can act as a protective factor against memory decline in those with existing high amounts of Alzheimer's disease pathology - a potentially significant advance that experts say could help alleviate some of dementia's most devastating outcomes. ![]() Disrupted sleep has previously been associated with faster accumulation of beta-amyloid protein in the brain. Fondazione Società Italiana di Neurologia.Deep sleep, also known as non-REM slow-wave sleep, can act as a "cognitive reserve factor" that may increase resilience against a protein in the brain called beta-amyloid that is linked to memory loss caused by dementia. However, in light of the clinical evidence of the few studies in the literature on the different types of disorders, more studies on the use of clonazepam (also in association with first choice treatments) are definitely needed.īruxism Clonazepam Insomnia Periodic leg movements REM sleep behavior disorder Restless legs syndrome. Our results indicate that the pharmacological treatment of sleep disorders with clonazepam must always be personalized according to the type of patient, the risk of addiction and the concomitant presence of respiratory disorders are key factors to take into account. A clear sleep-promoting effect of clonazepam was found also by meta-analysis. The studies included in the review involved patients with insomnia, REM sleep behavior disorder, sleep bruxism, and restless leg syndrome or PLMS which reported, most often, an increase in total sleep time with clonazepam. A random effects model meta-analysis was then carried out for the four more frequently reported polysomnographic measures: total sleep time, sleep latency, sleep efficiency, and periodic leg movement during sleep (PLMS) index.Ī total of 33 articles were retrieved and screened in full text, of which 18 met the criteria for review among the latter, nine met the criteria for meta-analysis. ![]() ![]() The objectives of this review and meta-analysis of polysomnographic data are those to focus on the clinical use of clonazepam for the management of sleep disorders by re-analyzing clinical trials and randomized clinical trials which have been published in peer-reviewed journals.Ī review of the literature including clinical trials and randomized controlled trials was performed in PubMed®, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement protocol.
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